Nova Clinic Guide
Types of Biostimulators: Differences Between Actives
Not all biostimulators are the same. The active ingredient, technique, and patient profile determine which makes the most sense.
Within the world of collagen biostimulators, there are different product types with different active ingredients and mechanisms. Understanding those differences helps in making better treatment decisions.
Types of biostimulators
The most widely used are based on poly-L-lactic acid and calcium hydroxyapatite. Both stimulate collagen production, but through slightly different pathways, with different textures, and with duration profiles that can vary.
Poly-L-lactic acid
A biodegradable polymer that acts as a controlled inflammatory stimulus to induce neocollagenesis. Its effect is very gradual. It typically requires multiple sessions, and results build over months.
Calcium hydroxyapatite
A naturally occurring mineral that acts as a scaffold and also stimulates collagen. It has a different consistency and can provide some immediate volume alongside the biological stimulus. Often used in areas where you want to combine support and stimulation.
Which is better?
There's no universal answer. It depends on the area being treated, the degree of laxity, the patient's profile, and the physician's experience with each product. At Novaclinic, we choose the product for the case — not the other way around. You can read more on our collagen biostimulators page.